Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.

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Autores principales:	Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f2
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spelling	oai:doaj.org-article:ecac0450d3ce4cd7a9cab854f96059f22021-11-21T12:35:23ZDistinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization10.1038/s41467-021-27075-02041-1723https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27075-0https://doaj.org/toc/2041-1723The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.Nikolas FriedrichEmanuel StiegelerMatthias GlöglThomas LemminSimon HansenClaus KadelkaYufan WuPatrick ErnstLiridona MaliqiCaio FoulkesMylène MorinMustafa ErogluThomas LiechtiBranislav IvanThomas ReinbergJonas V. SchaeferUmut KarakusStephan UrsprungAxel MannPeter RusertRoger D. KouyosJohn A. RobinsonHuldrych F. GünthardAndreas PlückthunAlexandra TrkolaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolas Friedrich Emanuel Stiegeler Matthias Glögl Thomas Lemmin Simon Hansen Claus Kadelka Yufan Wu Patrick Ernst Liridona Maliqi Caio Foulkes Mylène Morin Mustafa Eroglu Thomas Liechti Branislav Ivan Thomas Reinberg Jonas V. Schaefer Umut Karakus Stephan Ursprung Axel Mann Peter Rusert Roger D. Kouyos John A. Robinson Huldrych F. Günthard Andreas Plückthun Alexandra Trkola Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
description	The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.
format	article
author	Nikolas Friedrich Emanuel Stiegeler Matthias Glögl Thomas Lemmin Simon Hansen Claus Kadelka Yufan Wu Patrick Ernst Liridona Maliqi Caio Foulkes Mylène Morin Mustafa Eroglu Thomas Liechti Branislav Ivan Thomas Reinberg Jonas V. Schaefer Umut Karakus Stephan Ursprung Axel Mann Peter Rusert Roger D. Kouyos John A. Robinson Huldrych F. Günthard Andreas Plückthun Alexandra Trkola
author_facet	Nikolas Friedrich Emanuel Stiegeler Matthias Glögl Thomas Lemmin Simon Hansen Claus Kadelka Yufan Wu Patrick Ernst Liridona Maliqi Caio Foulkes Mylène Morin Mustafa Eroglu Thomas Liechti Branislav Ivan Thomas Reinberg Jonas V. Schaefer Umut Karakus Stephan Ursprung Axel Mann Peter Rusert Roger D. Kouyos John A. Robinson Huldrych F. Günthard Andreas Plückthun Alexandra Trkola
author_sort	Nikolas Friedrich
title	Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
title_short	Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
title_full	Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
title_fullStr	Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
title_full_unstemmed	Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
title_sort	distinct conformations of the hiv-1 v3 loop crown are targetable for broad neutralization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f2
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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

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