β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion

Excessive interferon (IFN) responses often follow viral infection to induce pathology or even death. Here the authors show that a signaling adaptor, β-arrestin 2, enhances the cGAS/STING innate immunity signaling pathway to promote IFN-β production, but may be degraded in infected cells to serve as...

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Autores principales: Yihua Zhang, Manman Li, Liuyan Li, Gui Qian, Yu Wang, Zijuan Chen, Jing Liu, Chao Fang, Feng Huang, Daqiao Guo, Quanming Zou, Yiwei Chu, Dapeng Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ecca9608f5234952bee68b8d7d3ab19c
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