Structural Evolution of TIR-Domain Signalosomes

Structural Evolution of TIR-Domain Signalosomes

TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and transient self-association and association with othe...

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Bibliographic Details
Main Authors: Surekha Nimma, Weixi Gu, Natsumi Maruta, Yan Li, Mengqi Pan, Forhad Karim Saikot, Bryan Y. J. Lim, Helen Ying McGuinness, Zannati Ferdous Zaoti, Sulin Li, Sneha Desa, Mohammad Kawsar Manik, Jeffrey D. Nanson, Bostjan Kobe
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
protein structure
protein-protein interactions
axon degeneration
cell-death signaling
signaling by cooperative assembly formation (SCAF)
innate immunity
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/ece1b08c56e44d039e4b4de42f74e856
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https://doaj.org/article/ece1b08c56e44d039e4b4de42f74e856

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