Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers

Yayun Xu,1– 3 Feihu Chen1– 3 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 2The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, Sch...

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Autores principales:	Xu Y, Chen F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	circular rnas rheumatoid arthritis fibroblast-like synoviocyte macrophage biomarkers cartilage pathogenesis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ecf59dad0f96459aa6cfc6e418c4570d
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spelling	oai:doaj.org-article:ecf59dad0f96459aa6cfc6e418c4570d2021-12-02T15:59:22ZCurrent Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers1178-7031https://doaj.org/article/ecf59dad0f96459aa6cfc6e418c4570d2021-03-01T00:00:00Zhttps://www.dovepress.com/current-status-of-functional-studies-on-circular-rnas-in-rheumatoid-ar-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Yayun Xu,1– 3 Feihu Chen1– 3 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 2The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, People’s Republic of China; 3School of Pharmacy, The Key Laboratory of Anti-Inflammatory and Immune Medicines, Ministry of Education, Hefei, People’s Republic of ChinaCorrespondence: Feihu ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, People’s Republic of ChinaEmail chenfeihu@ahmu.edu.cnAbstract: Circular RNAs (circRNAs), a new class of endogenous non-coding RNAs (ncRNAs), are highly stable and exhibit tissue-specific expression. Accumulating evidence has indicated that circRNAs play crucial roles in the development and progression of multiple diseases. Notably, circRNAs, important epigenetic modulators of gene expression in inflammation and autoimmune regulation, have a close association with the pathogenesis of rheumatoid arthritis (RA). RA, one of the most common systemic autoimmune diseases, is characterized by synovial hyperplasia and inflammation, and cartilage and bone destruction. Here, we focus on the roles of circRNAs in macrophage, synovial tissues, fibroblast-like synoviocytes (FLSs), and cartilage tissues in pathogenesis and progression of RA, highlighting the potential of circRNAs in the blood as diagnostic biomarkers, and aiming at providing new insights into the diagnosis and therapy of this disease.Keywords: circular RNAs, rheumatoid arthritis, fibroblast-like synoviocyte, macrophage, biomarkers, cartilage, pathogenesisXu YChen FDove Medical Pressarticlecircular rnasrheumatoid arthritisfibroblast-like synoviocytemacrophagebiomarkerscartilagepathogenesisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1185-1193 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular rnas rheumatoid arthritis fibroblast-like synoviocyte macrophage biomarkers cartilage pathogenesis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	circular rnas rheumatoid arthritis fibroblast-like synoviocyte macrophage biomarkers cartilage pathogenesis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Xu Y Chen F Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
description	Yayun Xu,1– 3 Feihu Chen1– 3 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 2The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, People’s Republic of China; 3School of Pharmacy, The Key Laboratory of Anti-Inflammatory and Immune Medicines, Ministry of Education, Hefei, People’s Republic of ChinaCorrespondence: Feihu ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, People’s Republic of ChinaEmail chenfeihu@ahmu.edu.cnAbstract: Circular RNAs (circRNAs), a new class of endogenous non-coding RNAs (ncRNAs), are highly stable and exhibit tissue-specific expression. Accumulating evidence has indicated that circRNAs play crucial roles in the development and progression of multiple diseases. Notably, circRNAs, important epigenetic modulators of gene expression in inflammation and autoimmune regulation, have a close association with the pathogenesis of rheumatoid arthritis (RA). RA, one of the most common systemic autoimmune diseases, is characterized by synovial hyperplasia and inflammation, and cartilage and bone destruction. Here, we focus on the roles of circRNAs in macrophage, synovial tissues, fibroblast-like synoviocytes (FLSs), and cartilage tissues in pathogenesis and progression of RA, highlighting the potential of circRNAs in the blood as diagnostic biomarkers, and aiming at providing new insights into the diagnosis and therapy of this disease.Keywords: circular RNAs, rheumatoid arthritis, fibroblast-like synoviocyte, macrophage, biomarkers, cartilage, pathogenesis
format	article
author	Xu Y Chen F
author_facet	Xu Y Chen F
author_sort	Xu Y
title	Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
title_short	Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
title_full	Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
title_fullStr	Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
title_full_unstemmed	Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
title_sort	current status of functional studies on circular rnas in rheumatoid arthritis and their potential role as diagnostic biomarkers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ecf59dad0f96459aa6cfc6e418c4570d
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Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers

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