Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.

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Autores principales:	Wen Hao Neo, Yiran Meng, Alba Rodriguez-Meira, Muhammad Z. H. Fadlullah, Christopher A. G. Booth, Emanuele Azzoni, Supat Thongjuea, Marella F. T. R. de Bruijn, Sten Eirik W. Jacobsen, Adam J. Mead, Georges Lacaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed0b6a3fcda745e28ef592ad042e36dd
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spelling	oai:doaj.org-article:ed0b6a3fcda745e28ef592ad042e36dd2021-12-05T12:22:00ZEzh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors10.1038/s41467-021-27140-82041-1723https://doaj.org/article/ed0b6a3fcda745e28ef592ad042e36dd2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27140-8https://doaj.org/toc/2041-1723Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.Wen Hao NeoYiran MengAlba Rodriguez-MeiraMuhammad Z. H. FadlullahChristopher A. G. BoothEmanuele AzzoniSupat ThongjueaMarella F. T. R. de BruijnSten Eirik W. JacobsenAdam J. MeadGeorges LacaudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Hao Neo Yiran Meng Alba Rodriguez-Meira Muhammad Z. H. Fadlullah Christopher A. G. Booth Emanuele Azzoni Supat Thongjuea Marella F. T. R. de Bruijn Sten Eirik W. Jacobsen Adam J. Mead Georges Lacaud Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
description	Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.
format	article
author	Wen Hao Neo Yiran Meng Alba Rodriguez-Meira Muhammad Z. H. Fadlullah Christopher A. G. Booth Emanuele Azzoni Supat Thongjuea Marella F. T. R. de Bruijn Sten Eirik W. Jacobsen Adam J. Mead Georges Lacaud
author_facet	Wen Hao Neo Yiran Meng Alba Rodriguez-Meira Muhammad Z. H. Fadlullah Christopher A. G. Booth Emanuele Azzoni Supat Thongjuea Marella F. T. R. de Bruijn Sten Eirik W. Jacobsen Adam J. Mead Georges Lacaud
author_sort	Wen Hao Neo
title	Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
title_short	Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
title_full	Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
title_fullStr	Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
title_full_unstemmed	Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
title_sort	ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed0b6a3fcda745e28ef592ad042e36dd
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Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

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