EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS

Аbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-...

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Autores principales: I. V. Shirinsky, V. S. Shirinsky
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Lenguaje:RU
Publicado: SPb RAACI 2014
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spelling oai:doaj.org-article:ed25acabc0804b49af3bc88b1b320fa72021-11-18T08:03:41ZEFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2011-1-101-104https://doaj.org/article/ed25acabc0804b49af3bc88b1b320fa72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/432https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-activated, EBV-speciлc CD4+T-cells than healthy donors. In  healthy controls, mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra did not cause sufлcient changes in  concentrations  of  CD4+,  IFN-γ+  cells.  Likewise,  there  was  no  detectable  in”uence  of  the  abovementioned  drugs upon the numbers of RA EBV-speciлc CD4+ , IFNγ+ cells. Thus, in RA patients, the antigen-induced activation of EBVspeciлc CD4+T-cells is reduced. Meanwhile, in vitro supplement with statins and the mentioned biological agents did not promote further suppression of this cell activity. (Med. Immunol., 2011, vol. 13, N 1, pp 101-104)I. V. ShirinskyV. S. ShirinskySPb RAACIarticlerheumatoid arthritisatherosclerosisimmunological markerstreatmentstatinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 101-104 (2014)
institution DOAJ
collection DOAJ
language RU
topic rheumatoid arthritis
atherosclerosis
immunological markers
treatment
statins
Immunologic diseases. Allergy
RC581-607
spellingShingle rheumatoid arthritis
atherosclerosis
immunological markers
treatment
statins
Immunologic diseases. Allergy
RC581-607
I. V. Shirinsky
V. S. Shirinsky
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
description Аbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-activated, EBV-speciлc CD4+T-cells than healthy donors. In  healthy controls, mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra did not cause sufлcient changes in  concentrations  of  CD4+,  IFN-γ+  cells.  Likewise,  there  was  no  detectable  in”uence  of  the  abovementioned  drugs upon the numbers of RA EBV-speciлc CD4+ , IFNγ+ cells. Thus, in RA patients, the antigen-induced activation of EBVspeciлc CD4+T-cells is reduced. Meanwhile, in vitro supplement with statins and the mentioned biological agents did not promote further suppression of this cell activity. (Med. Immunol., 2011, vol. 13, N 1, pp 101-104)
format article
author I. V. Shirinsky
V. S. Shirinsky
author_facet I. V. Shirinsky
V. S. Shirinsky
author_sort I. V. Shirinsky
title EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_short EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_fullStr EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full_unstemmed EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_sort effect of simvastatin therapy upon immunological markers of atherosclerosis in the patients with rheumatoid arthritis
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/ed25acabc0804b49af3bc88b1b320fa7
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