EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
Аbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-...
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oai:doaj.org-article:ed25acabc0804b49af3bc88b1b320fa72021-11-18T08:03:41ZEFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2011-1-101-104https://doaj.org/article/ed25acabc0804b49af3bc88b1b320fa72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/432https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-activated, EBV-speciлc CD4+T-cells than healthy donors. In healthy controls, mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra did not cause sufлcient changes in concentrations of CD4+, IFN-γ+ cells. Likewise, there was no detectable in”uence of the abovementioned drugs upon the numbers of RA EBV-speciлc CD4+ , IFNγ+ cells. Thus, in RA patients, the antigen-induced activation of EBVspeciлc CD4+T-cells is reduced. Meanwhile, in vitro supplement with statins and the mentioned biological agents did not promote further suppression of this cell activity. (Med. Immunol., 2011, vol. 13, N 1, pp 101-104)I. V. ShirinskyV. S. ShirinskySPb RAACIarticlerheumatoid arthritisatherosclerosisimmunological markerstreatmentstatinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 101-104 (2014) |
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rheumatoid arthritis atherosclerosis immunological markers treatment statins Immunologic diseases. Allergy RC581-607 |
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rheumatoid arthritis atherosclerosis immunological markers treatment statins Immunologic diseases. Allergy RC581-607 I. V. Shirinsky V. S. Shirinsky EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
description |
Аbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-activated, EBV-speciлc CD4+T-cells than healthy donors. In healthy controls, mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra did not cause sufлcient changes in concentrations of CD4+, IFN-γ+ cells. Likewise, there was no detectable in”uence of the abovementioned drugs upon the numbers of RA EBV-speciлc CD4+ , IFNγ+ cells. Thus, in RA patients, the antigen-induced activation of EBVspeciлc CD4+T-cells is reduced. Meanwhile, in vitro supplement with statins and the mentioned biological agents did not promote further suppression of this cell activity. (Med. Immunol., 2011, vol. 13, N 1, pp 101-104) |
format |
article |
author |
I. V. Shirinsky V. S. Shirinsky |
author_facet |
I. V. Shirinsky V. S. Shirinsky |
author_sort |
I. V. Shirinsky |
title |
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
title_short |
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
title_full |
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
title_fullStr |
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
title_full_unstemmed |
EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS |
title_sort |
effect of simvastatin therapy upon immunological markers of atherosclerosis in the patients with rheumatoid arthritis |
publisher |
SPb RAACI |
publishDate |
2014 |
url |
https://doaj.org/article/ed25acabc0804b49af3bc88b1b320fa7 |
work_keys_str_mv |
AT ivshirinsky effectofsimvastatintherapyuponimmunologicalmarkersofatherosclerosisinthepatientswithrheumatoidarthritis AT vsshirinsky effectofsimvastatintherapyuponimmunologicalmarkersofatherosclerosisinthepatientswithrheumatoidarthritis |
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1718422515487866880 |