Breakdown of supersaturation barrier links protein folding to amyloid formation

Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid pathway. This study is useful to the field of protein...

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Autores principales:	Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ed4d8eeda119466189e820b1da445527
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spelling	oai:doaj.org-article:ed4d8eeda119466189e820b1da4455272021-12-02T14:16:33ZBreakdown of supersaturation barrier links protein folding to amyloid formation10.1038/s42003-020-01641-62399-3642https://doaj.org/article/ed4d8eeda119466189e820b1da4455272021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01641-6https://doaj.org/toc/2399-3642Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid pathway. This study is useful to the field of protein folding versus self-assembly and amyloidogenesis.Masahiro NojiTatsushi SamejimaKeiichi YamaguchiMasatomo SoKeisuke YuzuEri ChataniYoko Akazawa-OgawaYoshihisa HagiharaYasushi KawataKensuke IkenakaHideki MochizukiJózsef KardosDaniel E. OtzenVittorio BellottiJohannes BuchnerYuji GotoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Masahiro Noji Tatsushi Samejima Keiichi Yamaguchi Masatomo So Keisuke Yuzu Eri Chatani Yoko Akazawa-Ogawa Yoshihisa Hagihara Yasushi Kawata Kensuke Ikenaka Hideki Mochizuki József Kardos Daniel E. Otzen Vittorio Bellotti Johannes Buchner Yuji Goto Breakdown of supersaturation barrier links protein folding to amyloid formation
description	Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid pathway. This study is useful to the field of protein folding versus self-assembly and amyloidogenesis.
format	article
author	Masahiro Noji Tatsushi Samejima Keiichi Yamaguchi Masatomo So Keisuke Yuzu Eri Chatani Yoko Akazawa-Ogawa Yoshihisa Hagihara Yasushi Kawata Kensuke Ikenaka Hideki Mochizuki József Kardos Daniel E. Otzen Vittorio Bellotti Johannes Buchner Yuji Goto
author_facet	Masahiro Noji Tatsushi Samejima Keiichi Yamaguchi Masatomo So Keisuke Yuzu Eri Chatani Yoko Akazawa-Ogawa Yoshihisa Hagihara Yasushi Kawata Kensuke Ikenaka Hideki Mochizuki József Kardos Daniel E. Otzen Vittorio Bellotti Johannes Buchner Yuji Goto
author_sort	Masahiro Noji
title	Breakdown of supersaturation barrier links protein folding to amyloid formation
title_short	Breakdown of supersaturation barrier links protein folding to amyloid formation
title_full	Breakdown of supersaturation barrier links protein folding to amyloid formation
title_fullStr	Breakdown of supersaturation barrier links protein folding to amyloid formation
title_full_unstemmed	Breakdown of supersaturation barrier links protein folding to amyloid formation
title_sort	breakdown of supersaturation barrier links protein folding to amyloid formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed4d8eeda119466189e820b1da445527
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_version_	1718391699953156096

Breakdown of supersaturation barrier links protein folding to amyloid formation

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