Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi

Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.

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Autores principales: Simone Früholz, Florian Fäßler, Üner Kolukisaoglu, Peter Pimpl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ed50d5b3d41147d8b468d89860ace1cd
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