Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi

Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.

Guardado en:

Detalles Bibliográficos
Autores principales:	Simone Früholz, Florian Fäßler, Üner Kolukisaoglu, Peter Pimpl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed50d5b3d41147d8b468d89860ace1cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed50d5b3d41147d8b468d89860ace1cd
record_format	dspace
spelling	oai:doaj.org-article:ed50d5b3d41147d8b468d89860ace1cd2021-12-02T14:38:53ZNanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi10.1038/s41467-018-02909-62041-1723https://doaj.org/article/ed50d5b3d41147d8b468d89860ace1cd2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02909-6https://doaj.org/toc/2041-1723Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.Simone FrüholzFlorian FäßlerÜner KolukisaogluPeter PimplNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simone Früholz Florian Fäßler Üner Kolukisaoglu Peter Pimpl Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
description	Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.
format	article
author	Simone Früholz Florian Fäßler Üner Kolukisaoglu Peter Pimpl
author_facet	Simone Früholz Florian Fäßler Üner Kolukisaoglu Peter Pimpl
author_sort	Simone Früholz
title	Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
title_short	Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
title_full	Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
title_fullStr	Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
title_full_unstemmed	Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
title_sort	nanobody-triggered lockdown of vsrs reveals ligand reloading in the golgi
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed50d5b3d41147d8b468d89860ace1cd
work_keys_str_mv	AT simonefruholz nanobodytriggeredlockdownofvsrsrevealsligandreloadinginthegolgi AT florianfaßler nanobodytriggeredlockdownofvsrsrevealsligandreloadinginthegolgi AT unerkolukisaoglu nanobodytriggeredlockdownofvsrsrevealsligandreloadinginthegolgi AT peterpimpl nanobodytriggeredlockdownofvsrsrevealsligandreloadinginthegolgi
_version_	1718390867965771776

Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi

Ejemplares similares