Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.

<h4>Background</h4>Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome. TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic R...

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Autores principales: Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Masaya Baba, Laura S Schmidt, W Marston Linehan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/ed5107496f554854b6c71b4e8083bdea
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