Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells....
Enregistré dans:
Auteurs principaux: | , , , , , , , , , , , , , , |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/ed56d705553641adb43a60033adc4409 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|