Focal brain lactate accumulation in metformin-induced encephalopathy without systemic lactic acidosis: A case report suggesting mitochondrial vulnerability in lentiform fork sign

Metformin causes metabolic encephalopathy in some patients with end-stage chronic kidney disease, resulting in impaired consciousness and parkinsonism. This encephalopathy has a very characteristic magnetic resonance imaging feature in lentiform nuclei known as the “lentiform fork sign”. However, th...

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Bibliographic Details
Main Authors: Akira Hanazono, Yoshiko Takahashi, Yui Sanpei, Sachiko Kamada, Masashiro Sugawara
Format: article
Language:EN
Published: Elsevier 2021
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Online Access:https://doaj.org/article/ed6278ae6dcb400d8536f17b6f9edd2c
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