USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells
Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule.
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ed69d97e703b4b0db8b927bb34b0aba6 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ed69d97e703b4b0db8b927bb34b0aba6 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ed69d97e703b4b0db8b927bb34b0aba62021-12-02T15:34:03ZUSP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells10.1038/s41467-018-03599-w2041-1723https://doaj.org/article/ed69d97e703b4b0db8b927bb34b0aba62018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03599-whttps://doaj.org/toc/2041-1723Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule.Achuth PadmanabhanNicholes CandelariaKwong-Kwok WongBryan C. NikolaiDavid M. LonardBert W. O’MalleyJoAnne S. RichardsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| description |
Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule. |
| format |
article |
| author |
Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards |
| author_facet |
Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards |
| author_sort |
Achuth Padmanabhan |
| title |
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_short |
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_full |
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_fullStr |
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_full_unstemmed |
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_sort |
usp15-dependent lysosomal pathway controls p53-r175h turnover in ovarian cancer cells |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ed69d97e703b4b0db8b927bb34b0aba6 |
| work_keys_str_mv |
AT achuthpadmanabhan usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT nicholescandelaria usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT kwongkwokwong usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT bryancnikolai usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT davidmlonard usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT bertwomalley usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells AT joannesrichards usp15dependentlysosomalpathwaycontrolsp53r175hturnoverinovariancancercells |
| _version_ |
1718386999420780544 |