Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational c...

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Autores principales: Daniel Grau, Yixiao Zhang, Chul-Hwan Lee, Marco Valencia-Sánchez, Jenny Zhang, Miao Wang, Marlene Holder, Vladimir Svetlov, Dongyan Tan, Evgeny Nudler, Danny Reinberg, Thomas Walz, Karim-Jean Armache
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ed6bec3062f3495c95ba56cf7a4fc536
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