Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Grau, Yixiao Zhang, Chul-Hwan Lee, Marco Valencia-Sánchez, Jenny Zhang, Miao Wang, Marlene Holder, Vladimir Svetlov, Dongyan Tan, Evgeny Nudler, Danny Reinberg, Thomas Walz, Karim-Jean Armache
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed6bec3062f3495c95ba56cf7a4fc536
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed6bec3062f3495c95ba56cf7a4fc536
record_format	dspace
spelling	oai:doaj.org-article:ed6bec3062f3495c95ba56cf7a4fc5362021-12-02T13:27:30ZStructures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction10.1038/s41467-020-20775-z2041-1723https://doaj.org/article/ed6bec3062f3495c95ba56cf7a4fc5362021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20775-zhttps://doaj.org/toc/2041-1723Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational changes during the process.Daniel GrauYixiao ZhangChul-Hwan LeeMarco Valencia-SánchezJenny ZhangMiao WangMarlene HolderVladimir SvetlovDongyan TanEvgeny NudlerDanny ReinbergThomas WalzKarim-Jean ArmacheNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Grau Yixiao Zhang Chul-Hwan Lee Marco Valencia-Sánchez Jenny Zhang Miao Wang Marlene Holder Vladimir Svetlov Dongyan Tan Evgeny Nudler Danny Reinberg Thomas Walz Karim-Jean Armache Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
description	Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational changes during the process.
format	article
author	Daniel Grau Yixiao Zhang Chul-Hwan Lee Marco Valencia-Sánchez Jenny Zhang Miao Wang Marlene Holder Vladimir Svetlov Dongyan Tan Evgeny Nudler Danny Reinberg Thomas Walz Karim-Jean Armache
author_facet	Daniel Grau Yixiao Zhang Chul-Hwan Lee Marco Valencia-Sánchez Jenny Zhang Miao Wang Marlene Holder Vladimir Svetlov Dongyan Tan Evgeny Nudler Danny Reinberg Thomas Walz Karim-Jean Armache
author_sort	Daniel Grau
title	Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
title_short	Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
title_full	Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
title_fullStr	Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
title_full_unstemmed	Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction
title_sort	structures of monomeric and dimeric prc2:ezh1 reveal flexible modules involved in chromatin compaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed6bec3062f3495c95ba56cf7a4fc536
work_keys_str_mv	AT danielgrau structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT yixiaozhang structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT chulhwanlee structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT marcovalenciasanchez structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT jennyzhang structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT miaowang structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT marleneholder structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT vladimirsvetlov structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT dongyantan structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT evgenynudler structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT dannyreinberg structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT thomaswalz structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction AT karimjeanarmache structuresofmonomericanddimericprc2ezh1revealflexiblemodulesinvolvedinchromatincompaction
_version_	1718393007838855168

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Ejemplares similares