Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates

Abstract 211At is a most promising radionuclide for targeted alpha therapy. However, its limited availability and poorly known basic chemistry hamper its use. Based on the analogy with iodine, labelling is performed via astatobenzoate conjugates, but in vivo deastatination occurs, particularly when...

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Autores principales: David Teze, Dumitru-Claudiu Sergentu, Valentina Kalichuk, Jacques Barbet, David Deniaud, Nicolas Galland, Rémi Maurice, Gilles Montavon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ed78f40f24454144bfa69cd69a69a850
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