Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

The molecular mechanisms leading to basal extrusion are unclear. Here, the authors use the Drosophila accessory gland to model human prostate acini and show that Ras/MAPK and PI3K/AKT/mTOR pathways are co-activated in two autocrine loops by dEGF and dIGF, inducing basal extrusion and subsequent tumo...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Amandine Rambur, Corinne Lours-Calet, Claude Beaudoin, Julio Buñay, Marine Vialat, Vincent Mirouse, Amalia Trousson, Yoan Renaud, Jean-Marc A. Lobaccaro, Silvère Baron, Laurent Morel, Cyrille de Joussineau
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/ed8781b6dc3c4f709135be407cfe9819
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/ed8781b6dc3c4f709135be407cfe9819

Documents similaires