Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

The molecular mechanisms leading to basal extrusion are unclear. Here, the authors use the Drosophila accessory gland to model human prostate acini and show that Ras/MAPK and PI3K/AKT/mTOR pathways are co-activated in two autocrine loops by dEGF and dIGF, inducing basal extrusion and subsequent tumo...

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Autores principales:	Amandine Rambur, Corinne Lours-Calet, Claude Beaudoin, Julio Buñay, Marine Vialat, Vincent Mirouse, Amalia Trousson, Yoan Renaud, Jean-Marc A. Lobaccaro, Silvère Baron, Laurent Morel, Cyrille de Joussineau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed8781b6dc3c4f709135be407cfe9819
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spelling	oai:doaj.org-article:ed8781b6dc3c4f709135be407cfe98192021-12-02T17:31:07ZSequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila10.1038/s41467-020-16123-w2041-1723https://doaj.org/article/ed8781b6dc3c4f709135be407cfe98192020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16123-whttps://doaj.org/toc/2041-1723The molecular mechanisms leading to basal extrusion are unclear. Here, the authors use the Drosophila accessory gland to model human prostate acini and show that Ras/MAPK and PI3K/AKT/mTOR pathways are co-activated in two autocrine loops by dEGF and dIGF, inducing basal extrusion and subsequent tumour formation.Amandine RamburCorinne Lours-CaletClaude BeaudoinJulio BuñayMarine VialatVincent MirouseAmalia TroussonYoan RenaudJean-Marc A. LobaccaroSilvère BaronLaurent MorelCyrille de JoussineauNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amandine Rambur Corinne Lours-Calet Claude Beaudoin Julio Buñay Marine Vialat Vincent Mirouse Amalia Trousson Yoan Renaud Jean-Marc A. Lobaccaro Silvère Baron Laurent Morel Cyrille de Joussineau Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
description	The molecular mechanisms leading to basal extrusion are unclear. Here, the authors use the Drosophila accessory gland to model human prostate acini and show that Ras/MAPK and PI3K/AKT/mTOR pathways are co-activated in two autocrine loops by dEGF and dIGF, inducing basal extrusion and subsequent tumour formation.
format	article
author	Amandine Rambur Corinne Lours-Calet Claude Beaudoin Julio Buñay Marine Vialat Vincent Mirouse Amalia Trousson Yoan Renaud Jean-Marc A. Lobaccaro Silvère Baron Laurent Morel Cyrille de Joussineau
author_facet	Amandine Rambur Corinne Lours-Calet Claude Beaudoin Julio Buñay Marine Vialat Vincent Mirouse Amalia Trousson Yoan Renaud Jean-Marc A. Lobaccaro Silvère Baron Laurent Morel Cyrille de Joussineau
author_sort	Amandine Rambur
title	Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
title_short	Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
title_full	Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
title_fullStr	Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
title_full_unstemmed	Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
title_sort	sequential ras/mapk and pi3k/akt/mtor pathways recruitment drives basal extrusion in the prostate-like gland of drosophila
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ed8781b6dc3c4f709135be407cfe9819
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Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

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