Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Abstract Microbial biofilms are involved in a number of infections that cannot be cured, as microbes in biofilms resist host immune defenses and antibiotic therapies. With no strict biofilm-antibiotic in the current pipelines, there is an unmet need for drug candidates that enable the current antibi...

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Main Authors: Jens Bo Andersen, Louise Dahl Hultqvist, Charlotte Uldahl Jansen, Tim Holm Jakobsen, Martin Nilsson, Morten Rybtke, Jesper Uhd, Blaine Gabriel Fritz, Roland Seifert, Jens Berthelsen, Thomas Eiland Nielsen, Katrine Qvortrup, Michael Givskov, Tim Tolker-Nielsen
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Microbial ecology
QR100-130
Online Access:https://doaj.org/article/eda8b498ebe14f64949aa92898bfab95
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https://doaj.org/article/eda8b498ebe14f64949aa92898bfab95

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