Accelerating functional gene discovery in osteoarthritis

Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.

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Autores principales:	Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
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spelling	oai:doaj.org-article:edbe1f565dfb4cb59b5b96ecd707f7bc2021-12-02T13:56:46ZAccelerating functional gene discovery in osteoarthritis10.1038/s41467-020-20761-52041-1723https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20761-5https://doaj.org/toc/2041-1723Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.Natalie C. ButterfieldKatherine F. CurryJulia SteinbergHannah DewhurstDavide Komla-EbriNaila S. MannanAnne-Tounsia AdoumVictoria D. LeitchJohn G. LoganJulian A. WaungElena GhirardelloLorraine SouthamScott E. YoultenJ. Mark WilkinsonElizabeth A. McAninchValerie E. VancollieFiona KussyJacqueline K. WhiteChristopher J. LelliottDavid J. AdamsRichard JacquesAntonio C. BiancoAlan BoydeEleftheria ZegginiPeter I. CroucherGraham R. WilliamsJ. H. Duncan BassettNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett Accelerating functional gene discovery in osteoarthritis
description	Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.
format	article
author	Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett
author_facet	Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett
author_sort	Natalie C. Butterfield
title	Accelerating functional gene discovery in osteoarthritis
title_short	Accelerating functional gene discovery in osteoarthritis
title_full	Accelerating functional gene discovery in osteoarthritis
title_fullStr	Accelerating functional gene discovery in osteoarthritis
title_full_unstemmed	Accelerating functional gene discovery in osteoarthritis
title_sort	accelerating functional gene discovery in osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
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Accelerating functional gene discovery in osteoarthritis

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