Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors

Abstract Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (PBAD). The intrinsic limitation of PBAD for the gene express...

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Autores principales: Chung-Jen Chiang, Po-Han Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ee22a175ea4c4ede806630b19979fd3b
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