Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacologica...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshinori Tsukumo, Tommy Alain, Bruno D. Fonseca, Robert Nadon, Nahum Sonenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ee562b6abcf44f1eadff64ef32118520
record_format	dspace
spelling	oai:doaj.org-article:ee562b6abcf44f1eadff64ef321185202021-12-02T16:50:15ZTranslation control during prolonged mTORC1 inhibition mediated by 4E-BP310.1038/ncomms117762041-1723https://doaj.org/article/ee562b6abcf44f1eadff64ef321185202016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11776https://doaj.org/toc/2041-1723The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.Yoshinori TsukumoTommy AlainBruno D. FonsecaRobert NadonNahum SonenbergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshinori Tsukumo Tommy Alain Bruno D. Fonseca Robert Nadon Nahum Sonenberg Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
description	The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.
format	article
author	Yoshinori Tsukumo Tommy Alain Bruno D. Fonseca Robert Nadon Nahum Sonenberg
author_facet	Yoshinori Tsukumo Tommy Alain Bruno D. Fonseca Robert Nadon Nahum Sonenberg
author_sort	Yoshinori Tsukumo
title	Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
title_short	Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
title_full	Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
title_fullStr	Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
title_full_unstemmed	Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
title_sort	translation control during prolonged mtorc1 inhibition mediated by 4e-bp3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
work_keys_str_mv	AT yoshinoritsukumo translationcontrolduringprolongedmtorc1inhibitionmediatedby4ebp3 AT tommyalain translationcontrolduringprolongedmtorc1inhibitionmediatedby4ebp3 AT brunodfonseca translationcontrolduringprolongedmtorc1inhibitionmediatedby4ebp3 AT robertnadon translationcontrolduringprolongedmtorc1inhibitionmediatedby4ebp3 AT nahumsonenberg translationcontrolduringprolongedmtorc1inhibitionmediatedby4ebp3
_version_	1718383074053455872

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Ejemplares similares