Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacologica...

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Autores principales: Yoshinori Tsukumo, Tommy Alain, Bruno D. Fonseca, Robert Nadon, Nahum Sonenberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
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