Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice

The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted...

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Autores principales:	Konstantin A. Tsetsarkin, Olga A. Maximova, Guangping Liu, Heather Kenney, Natalia Teterina, Marshall E. Bloom, Jeffrey M. Grabowski, Luwanika Mlera, Bianca M. Nagata, Ian Moore, Craig Martens, Emerito Amaro-Carambot, Elaine W. Lamirande, Stephen S. Whitehead, Alexander G. Pletnev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee7bfcbe055342979d1b86ee82672e3a
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spelling	oai:doaj.org-article:ee7bfcbe055342979d1b86ee82672e3a2021-12-02T17:31:26ZRoutes of Zika virus dissemination in the testis and epididymis of immunodeficient mice10.1038/s41467-018-07782-x2041-1723https://doaj.org/article/ee7bfcbe055342979d1b86ee82672e3a2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07782-xhttps://doaj.org/toc/2041-1723The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.Konstantin A. TsetsarkinOlga A. MaximovaGuangping LiuHeather KenneyNatalia TeterinaMarshall E. BloomJeffrey M. GrabowskiLuwanika MleraBianca M. NagataIan MooreCraig MartensEmerito Amaro-CarambotElaine W. LamirandeStephen S. WhiteheadAlexander G. PletnevNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstantin A. Tsetsarkin Olga A. Maximova Guangping Liu Heather Kenney Natalia Teterina Marshall E. Bloom Jeffrey M. Grabowski Luwanika Mlera Bianca M. Nagata Ian Moore Craig Martens Emerito Amaro-Carambot Elaine W. Lamirande Stephen S. Whitehead Alexander G. Pletnev Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
description	The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.
format	article
author	Konstantin A. Tsetsarkin Olga A. Maximova Guangping Liu Heather Kenney Natalia Teterina Marshall E. Bloom Jeffrey M. Grabowski Luwanika Mlera Bianca M. Nagata Ian Moore Craig Martens Emerito Amaro-Carambot Elaine W. Lamirande Stephen S. Whitehead Alexander G. Pletnev
author_facet	Konstantin A. Tsetsarkin Olga A. Maximova Guangping Liu Heather Kenney Natalia Teterina Marshall E. Bloom Jeffrey M. Grabowski Luwanika Mlera Bianca M. Nagata Ian Moore Craig Martens Emerito Amaro-Carambot Elaine W. Lamirande Stephen S. Whitehead Alexander G. Pletnev
author_sort	Konstantin A. Tsetsarkin
title	Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
title_short	Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
title_full	Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
title_fullStr	Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
title_full_unstemmed	Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
title_sort	routes of zika virus dissemination in the testis and epididymis of immunodeficient mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee7bfcbe055342979d1b86ee82672e3a
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Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice

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