Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function

Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with c...

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Autores principales:	Sierra Fox, Jacquelyn A. Myers, Christina Davidson, Michael Getman, Paul D. Kingsley, Nicholas Frankiewicz, Michael Bulger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ee98d3c56057456481faaea3dd0b0a5f
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spelling	oai:doaj.org-article:ee98d3c56057456481faaea3dd0b0a5f2021-12-02T19:12:30ZHyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function10.1038/s41467-020-18303-02041-1723https://doaj.org/article/ee98d3c56057456481faaea3dd0b0a5f2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18303-0https://doaj.org/toc/2041-1723Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with cell identity than super-enhancers.Sierra FoxJacquelyn A. MyersChristina DavidsonMichael GetmanPaul D. KingsleyNicholas FrankiewiczMichael BulgerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sierra Fox Jacquelyn A. Myers Christina Davidson Michael Getman Paul D. Kingsley Nicholas Frankiewicz Michael Bulger Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
description	Super-enhancer are usually defined by high levels of chromatin modification and associate with cell-specific gene expression. Here, the authors define hyperacetylated chromatin domains (HCDs) by using histone hyperacetylation peak breadth information and show that HCDs associated more closely with cell identity than super-enhancers.
format	article
author	Sierra Fox Jacquelyn A. Myers Christina Davidson Michael Getman Paul D. Kingsley Nicholas Frankiewicz Michael Bulger
author_facet	Sierra Fox Jacquelyn A. Myers Christina Davidson Michael Getman Paul D. Kingsley Nicholas Frankiewicz Michael Bulger
author_sort	Sierra Fox
title	Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_short	Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_full	Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_fullStr	Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_full_unstemmed	Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
title_sort	hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ee98d3c56057456481faaea3dd0b0a5f
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Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function

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