Structural design principles for specific ultra-high affinity interactions between colicins/pyocins and immunity proteins

Abstract The interactions of the antibiotic proteins colicins/pyocins with immunity proteins is a seminal model system for studying protein–protein interactions and specificity. Yet, a precise and quantitative determination of which structural elements and residues determine their binding affinity a...

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Bibliographic Details
Main Authors: Avital Shushan, Mickey Kosloff
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/eebc68ecefcd47f48e1af52640e17f11
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