Structural design principles for specific ultra-high affinity interactions between colicins/pyocins and immunity proteins

Abstract The interactions of the antibiotic proteins colicins/pyocins with immunity proteins is a seminal model system for studying protein–protein interactions and specificity. Yet, a precise and quantitative determination of which structural elements and residues determine their binding affinity a...

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Autores principales: Avital Shushan, Mickey Kosloff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/eebc68ecefcd47f48e1af52640e17f11
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