Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design

Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h...

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Auteurs principaux: Moganti Manasa, Nanjappa Shivakumar H.
Format: article
Langue:EN
Publié: De Gruyter 2021
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Accès en ligne:https://doaj.org/article/eec4960b7493483a913c537863d06eee
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