Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design

Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h...

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Autores principales:	Moganti Manasa, Nanjappa Shivakumar H.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	calcium carbonate floating tablets gastroretentive tablets mixture design optimization Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/eec4960b7493483a913c537863d06eee
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spelling	oai:doaj.org-article:eec4960b7493483a913c537863d06eee2021-12-05T14:10:47ZFormulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design1618-722910.1515/epoly-2021-0008https://doaj.org/article/eec4960b7493483a913c537863d06eee2021-01-01T00:00:00Zhttps://doi.org/10.1515/epoly-2021-0008https://doaj.org/toc/1618-7229Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h (R3) was elucidated. The optimized formulations developed by numerical optimization technique were found to have short floating lag time (2.85 ± 0.98 min), minimum burst release (27.02 ± 1.18%), and controlled yet near complete release (88.98 ± 2.75%) at 6 h. In vivo radiographic studies in rabbits indicated that optimized batch displayed a mean gastric retention time (GRT) of 5.5 ± 1 h which was significantly prolonged (P < 0.05) compared to the conventional tablets that displayed a GRT of less than 1 h. The studies proved that the gastroretentive tablets can be a promising platform to improve bioavailability of nutrients having absorption window in upper gastrointestinal tract.Moganti ManasaNanjappa Shivakumar H.De Gruyterarticlecalcium carbonatefloating tabletsgastroretentive tabletsmixture designoptimizationPolymers and polymer manufactureTP1080-1185ENe-Polymers, Vol 21, Iss 1, Pp 057-071 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium carbonate floating tablets gastroretentive tablets mixture design optimization Polymers and polymer manufacture TP1080-1185
spellingShingle	calcium carbonate floating tablets gastroretentive tablets mixture design optimization Polymers and polymer manufacture TP1080-1185 Moganti Manasa Nanjappa Shivakumar H. Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
description	Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h (R3) was elucidated. The optimized formulations developed by numerical optimization technique were found to have short floating lag time (2.85 ± 0.98 min), minimum burst release (27.02 ± 1.18%), and controlled yet near complete release (88.98 ± 2.75%) at 6 h. In vivo radiographic studies in rabbits indicated that optimized batch displayed a mean gastric retention time (GRT) of 5.5 ± 1 h which was significantly prolonged (P < 0.05) compared to the conventional tablets that displayed a GRT of less than 1 h. The studies proved that the gastroretentive tablets can be a promising platform to improve bioavailability of nutrients having absorption window in upper gastrointestinal tract.
format	article
author	Moganti Manasa Nanjappa Shivakumar H.
author_facet	Moganti Manasa Nanjappa Shivakumar H.
author_sort	Moganti Manasa
title	Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
title_short	Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
title_full	Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
title_fullStr	Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
title_full_unstemmed	Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
title_sort	formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using d-optimal mixture design
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/eec4960b7493483a913c537863d06eee
work_keys_str_mv	AT mogantimanasa formulationandoptimizationofgastroretentivebilayertabletsofcalciumcarbonateusingdoptimalmixturedesign AT nanjappashivakumarh formulationandoptimizationofgastroretentivebilayertabletsofcalciumcarbonateusingdoptimalmixturedesign
_version_	1718371752597258240

Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design

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