GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.

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Bibliographic Details
Main Authors: Paul G. Anastasiades, Andre Marques-Smith, Daniel Lyngholm, Tom Lickiss, Sayda Raffiq, Dennis Kätzel, Gero Miesenböck, Simon J. B. Butt
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/eecafeca6fe24e208afc545e3bdbe8ed
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Summary:GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.