An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells

Adherens junctions (AJs) mediate cell-cell adhesion between epithelial cells but tools to study their dynamic regulation are lacking. Here the authors develop an optochemical tool to stimulate the assembly of AJs through addition of a photocleavable tool and their dissociation upon exposure to light...

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Autores principales: Dirk Ollech, Tim Pflästerer, Adam Shellard, Chiara Zambarda, Joachim Pius Spatz, Philippe Marcq, Roberto Mayor, Richard Wombacher, Elisabetta Ada Cavalcanti-Adam
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/eedcc41d33c14987b2cfb07669f2953d
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