Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lipid membrane, and propose a kinetic model of force...

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Autores principales:	E. Nicholas Petersen, Hae-Won Chung, Arman Nayebosadri, Scott B. Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef25fc0a4a2e402685b431a30b4dbb41
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spelling	oai:doaj.org-article:ef25fc0a4a2e402685b431a30b4dbb412021-12-02T17:33:09ZKinetic disruption of lipid rafts is a mechanosensor for phospholipase D10.1038/ncomms138732041-1723https://doaj.org/article/ef25fc0a4a2e402685b431a30b4dbb412016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13873https://doaj.org/toc/2041-1723Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lipid membrane, and propose a kinetic model of force transduction.E. Nicholas PetersenHae-Won ChungArman NayebosadriScott B. HansenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q E. Nicholas Petersen Hae-Won Chung Arman Nayebosadri Scott B. Hansen Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
description	Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lipid membrane, and propose a kinetic model of force transduction.
format	article
author	E. Nicholas Petersen Hae-Won Chung Arman Nayebosadri Scott B. Hansen
author_facet	E. Nicholas Petersen Hae-Won Chung Arman Nayebosadri Scott B. Hansen
author_sort	E. Nicholas Petersen
title	Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
title_short	Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
title_full	Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
title_fullStr	Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
title_full_unstemmed	Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D
title_sort	kinetic disruption of lipid rafts is a mechanosensor for phospholipase d
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ef25fc0a4a2e402685b431a30b4dbb41
work_keys_str_mv	AT enicholaspetersen kineticdisruptionoflipidraftsisamechanosensorforphospholipased AT haewonchung kineticdisruptionoflipidraftsisamechanosensorforphospholipased AT armannayebosadri kineticdisruptionoflipidraftsisamechanosensorforphospholipased AT scottbhansen kineticdisruptionoflipidraftsisamechanosensorforphospholipased
_version_	1718380097156677632

Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

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