Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling.

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Autores principales:	Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef3433ccebdb4fec8e066692342a604d
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spelling	oai:doaj.org-article:ef3433ccebdb4fec8e066692342a604d2021-12-02T14:42:06ZOncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling10.1038/s41467-017-02002-42041-1723https://doaj.org/article/ef3433ccebdb4fec8e066692342a604d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02002-4https://doaj.org/toc/2041-1723Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling.Inma M. BerenjenoRoberto PiñeiroSandra D. CastilloWayne PearceNicholas McGranahanSally M. DewhurstValerie MenielNicolai J. BirkbakEvelyn LauLaurent SansregretDaniele MorelliNnennaya KanuShankar SrinivasMariona GrauperaVictoria E. R. ParkerKaren G. MontgomeryLarissa S. MonizCheryl L. ScudamoreWayne A. PhillipsRobert K. SempleAlan ClarkeCharles SwantonBart VanhaesebroeckNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inma M. Berenjeno Roberto Piñeiro Sandra D. Castillo Wayne Pearce Nicholas McGranahan Sally M. Dewhurst Valerie Meniel Nicolai J. Birkbak Evelyn Lau Laurent Sansregret Daniele Morelli Nnennaya Kanu Shankar Srinivas Mariona Graupera Victoria E. R. Parker Karen G. Montgomery Larissa S. Moniz Cheryl L. Scudamore Wayne A. Phillips Robert K. Semple Alan Clarke Charles Swanton Bart Vanhaesebroeck Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
description	Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling.
format	article
author	Inma M. Berenjeno Roberto Piñeiro Sandra D. Castillo Wayne Pearce Nicholas McGranahan Sally M. Dewhurst Valerie Meniel Nicolai J. Birkbak Evelyn Lau Laurent Sansregret Daniele Morelli Nnennaya Kanu Shankar Srinivas Mariona Graupera Victoria E. R. Parker Karen G. Montgomery Larissa S. Moniz Cheryl L. Scudamore Wayne A. Phillips Robert K. Semple Alan Clarke Charles Swanton Bart Vanhaesebroeck
author_facet	Inma M. Berenjeno Roberto Piñeiro Sandra D. Castillo Wayne Pearce Nicholas McGranahan Sally M. Dewhurst Valerie Meniel Nicolai J. Birkbak Evelyn Lau Laurent Sansregret Daniele Morelli Nnennaya Kanu Shankar Srinivas Mariona Graupera Victoria E. R. Parker Karen G. Montgomery Larissa S. Moniz Cheryl L. Scudamore Wayne A. Phillips Robert K. Semple Alan Clarke Charles Swanton Bart Vanhaesebroeck
author_sort	Inma M. Berenjeno
title	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
title_short	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
title_full	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
title_fullStr	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
title_full_unstemmed	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
title_sort	oncogenic pik3ca induces centrosome amplification and tolerance to genome doubling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ef3433ccebdb4fec8e066692342a604d
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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

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