Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses

The utility of patient-derived tumor cell lines as experimental models for glioblastoma has been challenged by limited representation of the in vivo tumor biology and low clinical translatability. Here, we report on longitudinal epigenetic and transcriptional profiling of seven glioblastoma spheroid...

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Autores principales: A.C. Nickel, D. Picard, N. Qin, M. Wolter, K. Kaulich, M. Hewera, D. Pauck, V. Marquardt, G. Torga, S. Muhammad, W. Zhang, O. Schnell, H.-J. Steiger, D. Hänggi, E. Fritsche, N.-G. Her, D.-H. Nam, M.S. Carro, M. Remke, G. Reifenberger, U.D. Kahlert
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/ef35d0cf9fa94f5e85dbd336eabcbef8
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