Super-complexes of adhesion GPCRs and neural guidance receptors

FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these three proteins form large super-complexes with functio...

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Autores principales:	Verity A. Jackson, Shahid Mehmood, Matthieu Chavent, Pietro Roversi, Maria Carrasquero, Daniel del Toro, Goenuel Seyit-Bremer, Fanomezana M. Ranaivoson, Davide Comoletti, Mark S. P. Sansom, Carol V. Robinson, Rüdiger Klein, Elena Seiradake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef384409442e4b9a8531b5fb0fc42da1
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spelling	oai:doaj.org-article:ef384409442e4b9a8531b5fb0fc42da12021-12-02T16:49:41ZSuper-complexes of adhesion GPCRs and neural guidance receptors10.1038/ncomms111842041-1723https://doaj.org/article/ef384409442e4b9a8531b5fb0fc42da12016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11184https://doaj.org/toc/2041-1723FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these three proteins form large super-complexes with functions distinct from their smaller subcomplexes.Verity A. JacksonShahid MehmoodMatthieu ChaventPietro RoversiMaria CarrasqueroDaniel del ToroGoenuel Seyit-BremerFanomezana M. RanaivosonDavide ComolettiMark S. P. SansomCarol V. RobinsonRüdiger KleinElena SeiradakeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Verity A. Jackson Shahid Mehmood Matthieu Chavent Pietro Roversi Maria Carrasquero Daniel del Toro Goenuel Seyit-Bremer Fanomezana M. Ranaivoson Davide Comoletti Mark S. P. Sansom Carol V. Robinson Rüdiger Klein Elena Seiradake Super-complexes of adhesion GPCRs and neural guidance receptors
description	FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these three proteins form large super-complexes with functions distinct from their smaller subcomplexes.
format	article
author	Verity A. Jackson Shahid Mehmood Matthieu Chavent Pietro Roversi Maria Carrasquero Daniel del Toro Goenuel Seyit-Bremer Fanomezana M. Ranaivoson Davide Comoletti Mark S. P. Sansom Carol V. Robinson Rüdiger Klein Elena Seiradake
author_facet	Verity A. Jackson Shahid Mehmood Matthieu Chavent Pietro Roversi Maria Carrasquero Daniel del Toro Goenuel Seyit-Bremer Fanomezana M. Ranaivoson Davide Comoletti Mark S. P. Sansom Carol V. Robinson Rüdiger Klein Elena Seiradake
author_sort	Verity A. Jackson
title	Super-complexes of adhesion GPCRs and neural guidance receptors
title_short	Super-complexes of adhesion GPCRs and neural guidance receptors
title_full	Super-complexes of adhesion GPCRs and neural guidance receptors
title_fullStr	Super-complexes of adhesion GPCRs and neural guidance receptors
title_full_unstemmed	Super-complexes of adhesion GPCRs and neural guidance receptors
title_sort	super-complexes of adhesion gpcrs and neural guidance receptors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ef384409442e4b9a8531b5fb0fc42da1
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Super-complexes of adhesion GPCRs and neural guidance receptors

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