Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour...

Full description

Saved in:
Bibliographic Details
Main Authors: Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436

Similar Items