Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour...

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Autores principales:	Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436
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spelling	oai:doaj.org-article:ef40f2fb5f1d4f3e935dd2d92c2e14362021-12-02T14:42:16ZEpigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival10.1038/s41467-017-01645-72041-1723https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e14362017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01645-7https://doaj.org/toc/2041-1723Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour growth.Marco SegattoRaffaella FittipaldiFabrizio PinRoberta SartoriKyung Dae KoHossein ZareClaudio FeniziaGianpietro ZanchettinElisa Sefora PierobonShinji HatakeyamaCosimo SpertiStefano MeriglianoMarco SandriPanagis FilippakopoulosPaola CostelliVittorio SartorelliGiuseppina CarettiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Segatto Raffaella Fittipaldi Fabrizio Pin Roberta Sartori Kyung Dae Ko Hossein Zare Claudio Fenizia Gianpietro Zanchettin Elisa Sefora Pierobon Shinji Hatakeyama Cosimo Sperti Stefano Merigliano Marco Sandri Panagis Filippakopoulos Paola Costelli Vittorio Sartorelli Giuseppina Caretti Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
description	Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour growth.
format	article
author	Marco Segatto Raffaella Fittipaldi Fabrizio Pin Roberta Sartori Kyung Dae Ko Hossein Zare Claudio Fenizia Gianpietro Zanchettin Elisa Sefora Pierobon Shinji Hatakeyama Cosimo Sperti Stefano Merigliano Marco Sandri Panagis Filippakopoulos Paola Costelli Vittorio Sartorelli Giuseppina Caretti
author_facet	Marco Segatto Raffaella Fittipaldi Fabrizio Pin Roberta Sartori Kyung Dae Ko Hossein Zare Claudio Fenizia Gianpietro Zanchettin Elisa Sefora Pierobon Shinji Hatakeyama Cosimo Sperti Stefano Merigliano Marco Sandri Panagis Filippakopoulos Paola Costelli Vittorio Sartorelli Giuseppina Caretti
author_sort	Marco Segatto
title	Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
title_short	Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
title_full	Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
title_fullStr	Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
title_full_unstemmed	Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
title_sort	epigenetic targeting of bromodomain protein brd4 counteracts cancer cachexia and prolongs survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436
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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

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