Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour...

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Auteurs principaux: Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
Q
Accès en ligne:https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436
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https://doaj.org/article/ef40f2fb5f1d4f3e935dd2d92c2e1436

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