Dual loss of human POLQ and LIG4 abolishes random integration

Homologous recombination mediated gene targeting is highly inefficient in human cells due to random integration events, Here the authors show that dual repression of polymerase θ and DNA ligase IV eliminate random integration events.

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Autores principales: Shinta Saito, Ryo Maeda, Noritaka Adachi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/ef54135e9bea42c6a525eac4bbb609dc
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