A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation.

Type 1 diabetes (T1D) is an organ-specific autoimmune disease, whereby immune cell-mediated killing leads to loss of the insulin-producing β cells in the pancreas. Genome-wide association studies (GWAS) have identified over 200 genetic variants associated with risk for T1D. The majority of the GWAS...

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Autores principales: Seung-Soo Kim, Adam D Hudgins, Jiping Yang, Yizhou Zhu, Zhidong Tu, Michael G Rosenfeld, Teresa P DiLorenzo, Yousin Suh
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/ef6473d563c743d89291adf7966b5f00
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