Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases.

Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases.

Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK activation. At low signal dose, ERK-1/2 is maximally phosphorylated but p38MAPK is minimally phosphorylated; as the signal dose increases, ERK-1/2 phosphorylation is reduced whereas p38MAPK phosphorylation is...

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Main Authors: Uddipan Sarma, Archana Sareen, Moitrayee Maiti, Vanita Kamat, Raki Sudan, Sushmita Pahari, Neetu Srivastava, Somenath Roy, Sitabhra Sinha, Indira Ghosh, Ajit G Chande, Robin Mukhopadhyaya, Bhaskar Saha
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/ef888165a46a4cb6b4641cee1ce83689
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https://doaj.org/article/ef888165a46a4cb6b4641cee1ce83689

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