Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic peptides—that show selectivity over other KDMs.
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Nature Portfolio
2017
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oai:doaj.org-article:ef8ec2f09725496691198a2fa7af4d882021-12-02T14:42:05ZHighly selective inhibition of histone demethylases by de novo macrocyclic peptides10.1038/ncomms147732041-1723https://doaj.org/article/ef8ec2f09725496691198a2fa7af4d882017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14773https://doaj.org/toc/2041-1723JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic peptides—that show selectivity over other KDMs.Akane KawamuraMartin MünzelTatsuya KojimaClarence YappBhaskar BhushanYuki GotoAnthony TumberTakayuki KatohOliver N. F. KingToby PassiouraLouise J. WalportStephanie B. HatchSarah MaddenSusanne MüllerPaul E. BrennanRasheduzzaman ChowdhuryRichard J. HopkinsonHiroaki SugaChristopher J. SchofieldNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Akane Kawamura Martin Münzel Tatsuya Kojima Clarence Yapp Bhaskar Bhushan Yuki Goto Anthony Tumber Takayuki Katoh Oliver N. F. King Toby Passioura Louise J. Walport Stephanie B. Hatch Sarah Madden Susanne Müller Paul E. Brennan Rasheduzzaman Chowdhury Richard J. Hopkinson Hiroaki Suga Christopher J. Schofield Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| description |
JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic peptides—that show selectivity over other KDMs. |
| format |
article |
| author |
Akane Kawamura Martin Münzel Tatsuya Kojima Clarence Yapp Bhaskar Bhushan Yuki Goto Anthony Tumber Takayuki Katoh Oliver N. F. King Toby Passioura Louise J. Walport Stephanie B. Hatch Sarah Madden Susanne Müller Paul E. Brennan Rasheduzzaman Chowdhury Richard J. Hopkinson Hiroaki Suga Christopher J. Schofield |
| author_facet |
Akane Kawamura Martin Münzel Tatsuya Kojima Clarence Yapp Bhaskar Bhushan Yuki Goto Anthony Tumber Takayuki Katoh Oliver N. F. King Toby Passioura Louise J. Walport Stephanie B. Hatch Sarah Madden Susanne Müller Paul E. Brennan Rasheduzzaman Chowdhury Richard J. Hopkinson Hiroaki Suga Christopher J. Schofield |
| author_sort |
Akane Kawamura |
| title |
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| title_short |
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| title_full |
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| title_fullStr |
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| title_full_unstemmed |
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| title_sort |
highly selective inhibition of histone demethylases by de novo macrocyclic peptides |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ef8ec2f09725496691198a2fa7af4d88 |
| work_keys_str_mv |
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| _version_ |
1718389845464711168 |