Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern

The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Comput...

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Autores principales:	Antonio J. Martín-Galiano, Francisco Díez-Fuertes, Michael J. McConnell, Daniel López
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 escape mutant HLA vaccine T cell epitope epidemic Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ef97a7e4b38a45e0b1cc6dfde71859aa
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spelling	oai:doaj.org-article:ef97a7e4b38a45e0b1cc6dfde71859aa2021-12-01T01:48:59ZPredicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern1664-322410.3389/fimmu.2021.732693https://doaj.org/article/ef97a7e4b38a45e0b1cc6dfde71859aa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.732693/fullhttps://doaj.org/toc/1664-3224The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.Antonio J. Martín-GalianoFrancisco Díez-FuertesMichael J. McConnellDaniel LópezFrontiers Media S.A.articleSARS-CoV-2escape mutantHLAvaccineT cell epitopeepidemicImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 escape mutant HLA vaccine T cell epitope epidemic Immunologic diseases. Allergy RC581-607
spellingShingle	SARS-CoV-2 escape mutant HLA vaccine T cell epitope epidemic Immunologic diseases. Allergy RC581-607 Antonio J. Martín-Galiano Francisco Díez-Fuertes Michael J. McConnell Daniel López Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
description	The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.
format	article
author	Antonio J. Martín-Galiano Francisco Díez-Fuertes Michael J. McConnell Daniel López
author_facet	Antonio J. Martín-Galiano Francisco Díez-Fuertes Michael J. McConnell Daniel López
author_sort	Antonio J. Martín-Galiano
title	Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_short	Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_full	Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_fullStr	Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_full_unstemmed	Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
title_sort	predicted epitope abundance supports vaccine-induced cytotoxic protection against sars-cov-2 variants of concern
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ef97a7e4b38a45e0b1cc6dfde71859aa
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Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern

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