A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

Human papilloma virus (HPV) E7 protein destabilizes the retinoblastoma protein (Rb) by inducing its ubiquitination in cervical cancer cells, however proteasomal degradation requires cleavage of Rb after Lys 810 and so far it has been unclear how Rb cleavage contributes to its degradation. Here, the...

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Autores principales: Takuya Tomita, Jon M. Huibregtse, Andreas Matouschek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/efa1fd80046b433d9c08b09e1c821f0f
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