Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleed...

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Bibliographic Details
Main Authors: Lucas H. Ting, Shirin Feghhi, Nikita Taparia, Annie O. Smith, Ari Karchin, Esther Lim, Alex St. John, Xu Wang, Tessa Rue, Nathan J. White, Nathan J. Sniadecki
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/efa71f194ad5411683dbacba59e216c2
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