Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleed...

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Auteurs principaux:	Lucas H. Ting, Shirin Feghhi, Nikita Taparia, Annie O. Smith, Ari Karchin, Esther Lim, Alex St. John, Xu Wang, Tessa Rue, Nathan J. White, Nathan J. Sniadecki
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/efa71f194ad5411683dbacba59e216c2
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spelling	oai:doaj.org-article:efa71f194ad5411683dbacba59e216c22021-12-02T16:58:13ZContractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk10.1038/s41467-019-09150-92041-1723https://doaj.org/article/efa71f194ad5411683dbacba59e216c22019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09150-9https://doaj.org/toc/2041-1723Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleeding risk in trauma patients.Lucas H. TingShirin FeghhiNikita TapariaAnnie O. SmithAri KarchinEsther LimAlex St. JohnXu WangTessa RueNathan J. WhiteNathan J. SniadeckiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucas H. Ting Shirin Feghhi Nikita Taparia Annie O. Smith Ari Karchin Esther Lim Alex St. John Xu Wang Tessa Rue Nathan J. White Nathan J. Sniadecki Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
description	Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleeding risk in trauma patients.
format	article
author	Lucas H. Ting Shirin Feghhi Nikita Taparia Annie O. Smith Ari Karchin Esther Lim Alex St. John Xu Wang Tessa Rue Nathan J. White Nathan J. Sniadecki
author_facet	Lucas H. Ting Shirin Feghhi Nikita Taparia Annie O. Smith Ari Karchin Esther Lim Alex St. John Xu Wang Tessa Rue Nathan J. White Nathan J. Sniadecki
author_sort	Lucas H. Ting
title	Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
title_short	Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
title_full	Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
title_fullStr	Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
title_full_unstemmed	Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
title_sort	contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/efa71f194ad5411683dbacba59e216c2
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Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

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