Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor L...
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Nature Portfolio
2016
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oai:doaj.org-article:efa9e82fc86e4339bfe2f9945de636862021-12-02T14:39:33ZGenome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA10.1038/ncomms111222041-1723https://doaj.org/article/efa9e82fc86e4339bfe2f9945de636862016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11122https://doaj.org/toc/2041-1723Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a).Johannes KettunenAyşe DemirkanPeter WürtzHarmen H.M. DraismaToomas HallerRajesh RawalAnika VaarhorstAntti J. KangasLeo-Pekka LyytikäinenMatti PirinenRené PoolAntti-Pekka SarinPasi SoininenTaru TukiainenQin WangMika TiainenTuulia TynkkynenNajaf AminTanja ZellerMarian BeekmanJoris DeelenKo Willems van DijkTõnu EskoJouke-Jan HottengaElisabeth M van LeeuwenTerho LehtimäkiEvelin MihailovRichard J. RoseAnton J.M. de CraenChristian GiegerMika KähönenMarkus PerolaStefan BlankenbergMarkku J. SavolainenAswin VerhoevenJorma ViikariGonneke WillemsenDorret I. BoomsmaCornelia M. van DuijnJohan ErikssonAntti JulaMarjo-Riitta JärvelinJaakko KaprioAndres MetspaluOlli RaitakariVeikko SalomaaP. Eline SlagboomMelanie WaldenbergerSamuli RipattiMika Ala-KorpelaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| description |
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a). |
| format |
article |
| author |
Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela |
| author_facet |
Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela |
| author_sort |
Johannes Kettunen |
| title |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_short |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_full |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_fullStr |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_full_unstemmed |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_sort |
genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of lpa |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/efa9e82fc86e4339bfe2f9945de63686 |
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