Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and...

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Autores principales:	Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G. Mirmira, Nahum Sonenberg, Ming Liu, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/effc74d97aa34c3f83d6c968e3443703
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spelling	oai:doaj.org-article:effc74d97aa34c3f83d6c968e34437032021-12-02T15:38:51ZLoss of mTORC1 signalling impairs β-cell homeostasis and insulin processing10.1038/ncomms160142041-1723https://doaj.org/article/effc74d97aa34c3f83d6c968e34437032017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16014https://doaj.org/toc/2041-1723Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.Manuel Blandino-RosanoRebecca BarbaressoMargarita Jimenez-PalomaresNadejda BozadjievaJoao Pedro Werneck-de-CastroMasayuki HatanakaRaghavendra G. MirmiraNahum SonenbergMing LiuMarkus A. RüeggMichael N. HallErnesto Bernal-MizrachiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
description	Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.
format	article
author	Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi
author_facet	Manuel Blandino-Rosano Rebecca Barbaresso Margarita Jimenez-Palomares Nadejda Bozadjieva Joao Pedro Werneck-de-Castro Masayuki Hatanaka Raghavendra G. Mirmira Nahum Sonenberg Ming Liu Markus A. Rüegg Michael N. Hall Ernesto Bernal-Mizrachi
author_sort	Manuel Blandino-Rosano
title	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_short	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_full	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_fullStr	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_full_unstemmed	Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
title_sort	loss of mtorc1 signalling impairs β-cell homeostasis and insulin processing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/effc74d97aa34c3f83d6c968e3443703
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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

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