PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production

Abstract We investigated the role of the PI3K p85α subunit in the development of acute colitis with a focus on intestinal macrophages. Experimental acute colitis was induced using 3% dextran sulfate sodium (DSS) in drinking water for 7 days. The severity of DSS-induced acute colitis was significantl...

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Autores principales: Shusaku Hayashi, Takayuki Hamada, Donald G. A. Zinsou, Momoe Oshiro, Kana Itoi, Takeshi Yamamoto, Makoto Kadowaki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f00f74519225490b8c7048e8656b5c28
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