Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice

Abstract Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly caused by deletion or mutation of the maternal allele of the UBE3A gene, with behavioral phenotypes and seizures as key features. Currently no treatment is available, and therapeutics are often ineffective in con...

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Autores principales: Heather A. Born, An T. Dao, Amber T. Levine, Wai Ling Lee, Natasha M. Mehta, Shubhangi Mehra, Edwin J. Weeber, Anne E. Anderson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f0286cef58f8494082fc0f0267c3148a
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