Modular actin nano-architecture enables podosome protrusion and mechanosensing

Podosomes are actin-based protrusions used by cells for invasion and local degradation but the structure underlying their protrusiveness and mechanosensitivity is unclear. Here, the authors report that podosomes have a modular actin nano-architecture whose organization differs on stiff or soft subst...

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Autores principales:	Koen van den Dries, Leila Nahidiazar, Johan A. Slotman, Marjolein B. M. Meddens, Elvis Pandzic, Ben Joosten, Marleen Ansems, Joost Schouwstra, Anke Meijer, Raymond Steen, Mietske Wijers, Jack Fransen, Adriaan B. Houtsmuller, Paul W. Wiseman, Kees Jalink, Alessandra Cambi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f02ec8baa69243f385139e1d26c11672
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spelling	oai:doaj.org-article:f02ec8baa69243f385139e1d26c116722021-12-02T14:38:39ZModular actin nano-architecture enables podosome protrusion and mechanosensing10.1038/s41467-019-13123-32041-1723https://doaj.org/article/f02ec8baa69243f385139e1d26c116722019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13123-3https://doaj.org/toc/2041-1723Podosomes are actin-based protrusions used by cells for invasion and local degradation but the structure underlying their protrusiveness and mechanosensitivity is unclear. Here, the authors report that podosomes have a modular actin nano-architecture whose organization differs on stiff or soft substrates.Koen van den DriesLeila NahidiazarJohan A. SlotmanMarjolein B. M. MeddensElvis PandzicBen JoostenMarleen AnsemsJoost SchouwstraAnke MeijerRaymond SteenMietske WijersJack FransenAdriaan B. HoutsmullerPaul W. WisemanKees JalinkAlessandra CambiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koen van den Dries Leila Nahidiazar Johan A. Slotman Marjolein B. M. Meddens Elvis Pandzic Ben Joosten Marleen Ansems Joost Schouwstra Anke Meijer Raymond Steen Mietske Wijers Jack Fransen Adriaan B. Houtsmuller Paul W. Wiseman Kees Jalink Alessandra Cambi Modular actin nano-architecture enables podosome protrusion and mechanosensing
description	Podosomes are actin-based protrusions used by cells for invasion and local degradation but the structure underlying their protrusiveness and mechanosensitivity is unclear. Here, the authors report that podosomes have a modular actin nano-architecture whose organization differs on stiff or soft substrates.
format	article
author	Koen van den Dries Leila Nahidiazar Johan A. Slotman Marjolein B. M. Meddens Elvis Pandzic Ben Joosten Marleen Ansems Joost Schouwstra Anke Meijer Raymond Steen Mietske Wijers Jack Fransen Adriaan B. Houtsmuller Paul W. Wiseman Kees Jalink Alessandra Cambi
author_facet	Koen van den Dries Leila Nahidiazar Johan A. Slotman Marjolein B. M. Meddens Elvis Pandzic Ben Joosten Marleen Ansems Joost Schouwstra Anke Meijer Raymond Steen Mietske Wijers Jack Fransen Adriaan B. Houtsmuller Paul W. Wiseman Kees Jalink Alessandra Cambi
author_sort	Koen van den Dries
title	Modular actin nano-architecture enables podosome protrusion and mechanosensing
title_short	Modular actin nano-architecture enables podosome protrusion and mechanosensing
title_full	Modular actin nano-architecture enables podosome protrusion and mechanosensing
title_fullStr	Modular actin nano-architecture enables podosome protrusion and mechanosensing
title_full_unstemmed	Modular actin nano-architecture enables podosome protrusion and mechanosensing
title_sort	modular actin nano-architecture enables podosome protrusion and mechanosensing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f02ec8baa69243f385139e1d26c11672
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Modular actin nano-architecture enables podosome protrusion and mechanosensing

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